Therapies engineered to prolong clotting factor protein circulation time manipulate the balance of pro-coagulant and anti-coagulant proteins or introduce new genetic material to enable endogenous factor protein production dominate the clinical trial landscape of hemophilia. Hemophilia B or Christmas disease is a genetic bleeding disorder resulting in the lack of ability to produce blood-clotting factor IX FIX. New Gene Therapy For Hemophilia Elearning Module Hemophilia World News Find a Pfizer study thats right for you by searching for conditions keywords or a National Clinical Trials NCT number. Hemophilia clinical trials . Seasonal allergies at time of dosing or clinical findings at Screening. A randomized clinical trial of prophylaxis in children with hemophilia A the ESPRIT Study This randomized trial confirms the efficacy of prophylaxis in preventing bleeds and arthropathy in children with hemophilia particularly when it is initiated early in life. 1Hematology and Transfusion